Journal
MACROMOLECULAR CHEMISTRY AND PHYSICS
Volume 212, Issue 6, Pages 643-651Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201000735
Keywords
biocompatibility; block copolymers; drug delivery; micelles
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Funding
- Natural Science Foundation of China [NSFC-20774082, 50830106]
- Foundation of Ministry of Education of China [20070335024]
- Science Foundation of Chinese University
- State Key Laboratory of Supramolecular Structure and Materials [SKLSSM200911]
- Natural Science Foundation of China of Zhejiang Province [Y4080250]
- National Science Fund for Distinguished Young Scholars [51025312]
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Well-defined amphiphilic PLA-b-PMPC diblock copolymers were synthesized. Bimimetic micelles were prepared and applied for release of anti-cancer drugs (DOX). TEM and DLS analysis revealed a regular spherical shape with small diameter (less than 50 nm) of the micelle. The biocompatibility of PLA-b-PMPC micelles was studied, and it was found that the micelles possessed excellent cytocompatibility due to the zwitterionic phosphorylcholine group. DOX could be efficiently loaded into the micelles with a loading efficiency of 44-67%. The DOX-loaded micelles showed lower cytotoxicity than free drugs and efficiently delivered and released the drug into cancer cells. With these properties, the PLA-b-PMPC polymer micelles are attractive as drug carriers for pharmaceutical application.
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