Journal
MACROMOLECULAR CHEMISTRY AND PHYSICS
Volume 212, Issue 11, Pages 1185-1192Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.201100007
Keywords
block copolymers; drug delivery systems; micelles; nanoparticles; stimuli-sensitive polymers
Categories
Funding
- NIH [R01CA129189]
- NSF [BES0547613]
- National Natural Science Foundation of China [1004030, 50873080]
- Natural Science Foundation of Jiangsu Province of China [BK2010145]
- Fundamental Research Funds for the Central Universities of China [JUSRP21013]
Ask authors/readers for more resources
Amphiphilic block copolymers (PEG-b-PEYM) bearing acid-labile ortho ester pendant chains were synthesized by atom transfer radical polymerization, and the effect of chain-length of the ortho-ester-bearing PEYM block on micelle properties was investigated. The length of the PEYM block affected the critical micelle concentration and pH-dependent average particle size but not the kinetics of side-chain hydrolysis. A hydrophobic dye, Nile red, was loaded in the micelles. Both the loading content and the size of the loaded micelles were influenced by the length of the PEYM block, whereas the release kinetics of Nile red was not. Provided that these acid-labile micelles are completely cell compatible, they are potentially useful bio-responsive nanocarriers for enhancing the efficacy of hydrophobic drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available