Journal
MACROMOLECULAR CHEMISTRY AND PHYSICS
Volume 211, Issue 12, Pages 1369-1376Publisher
WILEY-BLACKWELL
DOI: 10.1002/macp.200900672
Keywords
atom-transfer radical polymerization (ATRP); dendrimers; F-19 contrast agents; fluorinated polymers; polymeric nanoparticles
Categories
Funding
- Japan Society for the Promotion of Science (JSPS)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
Ask authors/readers for more resources
Novel fluorinated polymer nanoparticles (PNPs) for F-19 MRI were prepared by living radical polymerization initiated by a dendrimer. The dendritic macroinitiator with Br substituents was synthesized from hydroxy-group-terminated G2 polyamidoamine dendrimers. The arborescent fluorinated polymers of 2,2,3,3-tetrafluoropropyl methacrylate and 2,2,2-trifluoroethyl methacrylate were characterized in molecular weight, the number of arms, the degree of polymerization per arm, and the diameter as a whole. The PNP diameter was precisely controlled by the molecular weight in the range of 3-25 nm. In addition, the fluorinated PNP gave a narrow resonance by F-19 NMR spectroscopy. These results indicate that the fluorinated PNP can be used as a new type of F-19 MRI agent.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available