Journal
MACROMOLECULAR CHEMISTRY AND PHYSICS
Volume 209, Issue 21, Pages 2180-2193Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.200800337
Keywords
atom transfer radical polymerisation; AGET; bioconjugate; biomolecules; click chemistry; (DP)over-bar; functionality; inverse miniemulsion
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Funding
- National Science Foundation [DMR-05-49353]
- National Tissue Engineering Center [DAMA 17-02-0717]
- National Institutes of Health [RO1 DE15392]
- CRP Consortium
- Natural Sciences and Engineering Research Council (NSERC) Postdoctoral Fellowship of Canada
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Functionality, one of the key attributes of atom transfer radical polymerization (ATRP), was utilized for the synthesis of well-controlled polymers functionalized with biotin, pyrene, and peptides. Hydroxy-functionalized poly(oligo (ethylene oxide) monomethyl ether methacrylate) (HO-POEOMA) was prepared by AGET ATRP of OEOMA initiated by 2-hydroxyethyl 2-bromoisobutyrate in water or in inverse miniemulsion of water/cyclohexane at ambient temperature. HO-POEOMA was then further functionalized with biotin, pyrene, and GRGDS peptide. In addition, ATRP and click chemistry offered an efficient route for the synthesis of telechelic di-biotin polymers. These general method can be applied to the formation of different functional materials conjugated with proteins, dyes, nucleic acids, and drugs.
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