Journal
MACROMOLECULAR BIOSCIENCE
Volume 14, Issue 5, Pages 731-739Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300406
Keywords
degradation; hydrogels; matrix metalloproteinases; PEGDA; porosity
Funding
- National Science Foundation [EEC-1157041]
- Pritzker Institute of Biomedical Science and Engineering at the Illinois Institute of Technology
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Proteolytically degradable poly(ethylene) glycol (PEG) hydrogels have been investigated as tissue engineering scaffolds; however, cell invasion and tissue regeneration are limited by the rate of cell-mediated degradation due to the small mesh size of the resultant crosslinked network. Gelatin leaching is combined with photopolymerization to form porous matrix-metalloproteinase (MMP)-sensitive PEG scaffolds under cytocompatible conditions in the presence of cells. Gelatin leaching allows control over pore size and porosity through selectivity of gelatin bead particle size and porogen loading, respectively. Increases in porogen loading lead to increased porosity, decreased compressive modulus and degradation time, and enhanced proliferation of encapsulated vascular smooth muscle cells.
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