Journal
MACROMOLECULAR BIOSCIENCE
Volume 15, Issue 4, Pages 568-582Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400438
Keywords
controlled release; multi-drug loading; nanoparticle scaffold; peptides; self-assembly
Funding
- Department of Chemistry at Michigan Technological University
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Peptide-functionalized polymeric nanoparticles were designed and self-assembled into continuous nanoparticle fibers and three-dimensional scaffolds via ionic complementary peptide interaction. Different nanoparticle compositions can be designed to be appropriate for each desired drug, so that the release of each drug is individually controlled and the simultaneous sustainable release of multiple drugs is achieved in a single scaffold. A self-assembled scaffold membrane was incubated with NIH3T3 fibroblast cells in a culture dish that demonstrated non-toxicity and non-inhibition on cell proliferation. This type of nanoparticle scaffold combines the advantages of peptide self-assembly and the versatility of polymeric nanoparticle controlled release systems for tissue engineering.
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