Journal
MACROMOLECULAR BIOSCIENCE
Volume 14, Issue 12, Pages 1795-1806Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400290
Keywords
dispersion; doxorubicin; pH responsive; single walled carbon nanotubes (SWCNTs); target specific killing
Funding
- CSIR, India (ADD) [CSC0302]
- DST, India [SR/S1/OC-25/2011]
- CSIR, India
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Cholesterol-based dipeptide carboxylates were synthesized and exploited for the pH responsive reversible dispersion and precipitation of single walled carbon nanotube (SWCNT) in water specifically at tumorogenic environmental pH (6.0-6.5). The nanohybrid showed excellent pH responsive drug release between pH range of 6.0 and 6.5. The exfoliation of SWCNTs was characterized by microscopic and spectroscopic studies. Importantly, drug-loaded SWCNT dispersions showed better killing efficiency compared to that of the native drug and were highly efficient in selective killing of cancer cells (Hela, HepG2) with 2.5-fold higher efficacy compared to that of normal cells (CHO, NIH3T3).
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