Journal
MACROMOLECULAR BIOSCIENCE
Volume 15, Issue 3, Pages 372-384Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400376
Keywords
amphiphiles; biodegradable; cell migration; PCL-PEG; Rho GTPases
Funding
- National Natural Science Foundation of China [31300775, 11372203, 11172189]
- National Key Technology R & D Program of China [2012BAI18B02]
- Visiting Scholar Foundation of MOE Key Laboratory of Biorheological Science and Technology (Chongqing University) [CQKLBST-2012-006]
- Specialized Research Fund for the Doctoral Program of Higher Education [20120181120058]
- National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China [J1103604]
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Uptake of nanoparticles (NPs) affects cell migration but the mechanism remains poorly understood. In this study, the amphiphilic block PCL-PEG nano-micelles with well-controlled hydrophilic/hydrophobic chains were used to investigate the effect of internalized nano-micelles on cancer cell migration. Our results indicated that the nano-micelles with medium PCL and PEG chains increased expression of Rho GTPases and impeded focal adhesion components. This could enhance Hep G2 cell motility. The nano-micelles with large PCL and PEG chains showed lower Rho GTPase levels and higher FA components. This is consistent with slower cell migration. Understanding the mechanism of NPs regulating cell behaviors may help the design of efficient drug delivery systems based on polymer micelles.
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