Journal
MACROMOLECULAR BIOSCIENCE
Volume 15, Issue 2, Pages 183-199Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400362
Keywords
drug delivery; nanocarriers; nanomedicine; theranostics; thermoresponsive
Funding
- Bundesministerium fur Bildung und Forschung (BMBF) through the NanoMatFutur award [13N12561]
- Helmholtz Virtual Institute, Multifunctional Biomaterials for Medicine
- Freie Universitat Focus Area Nanoscale
- Deutsche Forschungsgemeinschaft (DFG)/German Research Foundation [SFB1112]
- Dahlem Research Center through the Dahlem International Network Postdocs program
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In the last couple of decades several drug carriers have been tailored on the nanometric scale by taking advantage of new stimuli responsive materials. Thermoresponsive polymers in particular have been extensively employed as stimuli-responsive building blocks that in combination with other environmental-responsive materials allowed the birth of smarter systems that can respond to more than one stimulus. Examples that highlight the different polymers for thermally triggered drug delivery will be described. A special emphasis will be given to the description of novel theranostic nanodevices that combine more than one responsive modality in order to create a local hyperthermia that leads to the polymer phase transition and triggered drug release, cell recognition, and/or appearance of an imaging signal.
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