Journal
MACROMOLECULAR BIOSCIENCE
Volume 14, Issue 8, Pages 1181-1189Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400052
Keywords
cell adhesion peptide; decellularized vein matrix; endothelial progenitor cells; endothelialization; polydopamine
Funding
- National Research Foundation of Korea (NRF) [NRF-2013R1A1A2A10061422]
- Translational Research Center for Protein Function Control (TRCP) - Ministry of Science, ICT & Future Planning (MSIP), Republic of Korea [2009-0083522]
- Korea Health Technology R&D Project - Ministry of Health & Welfare, Republic of Korea [A110552]
- Korea Health Promotion Institute [A110552] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Enhanced endothelialization of tissue-engineered blood vessels is essential for vascular regeneration and function of engineered vessels. In this study, mussel-inspired surface chemistry of polydopamine (pDA) coatings are applied to functionalize decellularized vein matrix (DVM) with extracellular matrix-derived cell adhesion peptides (RGD and YIGSR). DVMs engineered with pDA-peptides enhance focal adhesion, metabolic activity, and endothelial differentiation of human endothelial progenitor cells (EPCs) derived from cord blood and embryonic stem cells compared with EPCs on non-coated or pDA-coated DVMs. These results indicate that pDA-peptide functionalization may contribute to enhanced, rapid endothelialization of DVM surfaces by promoting adhesion, proliferation, and differentiation of circulating EPCs. Ultimately, this approach may be useful for improving in vivo patency and function of decellularized matrix-based blood vessels.
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