Journal
MACROMOLECULAR BIOSCIENCE
Volume 14, Issue 5, Pages 643-654Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300420
Keywords
anti-inflammatory drugs; biological properties; blood compatibility; copolymerization; glycidol
Funding
- DFG collaborative SFB 765 research center
- Dahlem Research School
- BMBF project MODIAMD [FKZ: 13N10351]
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In this study, the extent to which the scaffold architecture of polyglycerol sulfates affects inflammatory processes and hemocompatibility is investigated. Competitive L-selectin binding assays, cellular uptake studies, and blood compatibility readouts are done to evaluate distinct biological properties. Fully glycerol based hyperbranched polyglycerol architectures are obtained by either homopolymerization of glycidol (60% branching) or a new copolymerization strategy of glycidol with ethoxyethyl glycidyl ether. Two polyglycerols with 24 and 42% degree of branching (DB) are synthesized by using different monomer feed ratios. A perfectly branched polyglycerol dendrimer is synthesized according to an iterative two-step protocol based on allylation of the alcohol and subsequent catalytic dihydroxylation. All the polyglycerol sulfates are synthesized with a comparable molecular weight and degree of sulfation. The DB make the different polymer conjugates perform different ways. The optimal DB is 60% in all biological assays.
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