Journal
MACROMOLECULAR BIOSCIENCE
Volume 15, Issue 2, Pages 262-274Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400339
Keywords
organic-inorganic hybrid composites; porosity; proliferation and osteoblastic differentiation of cells; sol-gel processes; thermomechanical properties
Funding
- European Social Fund (ESF)
- Greek State [NARGEL-PE5(2551)]
- Generalitat Valenciana through VALi+d grant [ACIF/2010/238]
- Portuguese Foundation for Science and Technology (FCT) [PTDC/FIS/115048/2009]
- Ministerio de Economia y Competitividad, MINECO [MAT2013-46467-C4-1-R]
- VI National R&D&I Plan, Iniciativa Ingenio, Consolider Program, CIBER Actions
- Instituto de Salud Carlos III
- European Regional Development Fund
- Fundação para a Ciência e a Tecnologia [PTDC/FIS/115048/2009] Funding Source: FCT
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A novel approach to reinforce polymer porous membranes is presented. In the prepared hybrid materials, the inorganic phase of silica is synthesized in-situ and inside the pores of aminolyzed polylactic acid (PLA) membranes by sol-gel reactions using tetraethylorthosilicate (TEOS) and glycidoxypropyltrimethoxysilane (GPTMS) as precursors. The hybrid materials present a porous structure with a silica layer covering the walls of the pores while GPTMS serves also as coupling agent between the organic and inorganic phase. The adjustment of silica precursors ratio allows the modulation of the thermomechanical properties. Culture of mesenchymal stem cells on these supports in osteogenic medium shows the expression of characteristic osteoblastic markers and the mineralization of the extracellular matrix.
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