Journal
MACROMOLECULAR BIOSCIENCE
Volume 13, Issue 10, Pages 1431-1437Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300233
Keywords
biodegradable biomaterials; coatings; composites; drug delivery
Funding
- Alexander von Humboldt Foundation
- German Research Foundation (Deutsche Forschungsgemeinschaft) [DFG SCHE 603/4-3]
- German Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung) [BMBF 13N11340]
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Silk protein-based materials are promising materials for the delivery of drugs and other active ingredients, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) in combination with either a polyester (polycaprolactone) or a polyurethane (pellethane), and their physical properties are described. The release profiles are affected by both the film composition and the presence of enzymes, and release can be observed over a period of several weeks. Such silk-based composites have potential as drug eluting biocompatible coatings or implantable devices.
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