Journal
MACROMOLECULAR BIOSCIENCE
Volume 13, Issue 5, Pages 551-561Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200471
Keywords
additive manufacturing; cartilage; gelatin; hydrogels; tissue engineering
Funding
- Australian Research Council
- European Union [PIOF-GA-2010-272286]
- Dutch Arthritis Foundation
- NICHD
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Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. GelMA solutions have a low viscosity at 37 degrees C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or co-deposition with thermoplastics allows gelMA to be used in biofabrication processes. These attributes may allow engineered constructs to match the natural functional variations in cartilage mechanical and geometrical properties.
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