Journal
MACROMOLECULAR BIOSCIENCE
Volume 13, Issue 8, Pages 1020-1035Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300013
Keywords
biomaterial; eri; fibroin; Samia ricini; silk
Funding
- Department of Biotechnology (NER Programme) and its Bioinformatics facilities
- Department of Science and Technology, Government of India, New Delhi
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Mulberry silk fibroin is a widely used biomaterial and recent work on non-mulberry silk fibroin also suggests it may have similar uses. We expect silk fibroin from the only domesticated non-mulberry eri silkworm, Samia ricini, to possess useful properties as a biomaterial. Eri silk gland fibroin is a heterodimeric protein of approximately 450kDa. Cytocompatibility evaluation with fibroblasts and osteoblast-like cells shows good cell attachment, viability and proliferation. The matrices, which have high thermal stability and good swellability, are also haemocompatible. Eri silk production is cost effective as no agronomic practices are required for their host plant cultivation. This fibroin provide new opportunities as an alternative natural functional biomaterial in various biomedical applications.
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