Journal
MACROMOLECULAR BIOSCIENCE
Volume 13, Issue 5, Pages 623-632Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200396
Keywords
aggregation-induced emission; drug carriers; fluorescence; micelles; optical imaging
Funding
- National Science Council of ROC [NSC 99-2218-E-006-253, NSC 100-2221-E-006-072]
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A new type of fluorescent polymeric micelles is developed by self-assembly from a series of amphiphilic block copolymers, poly(ethylene glycol)-b-poly[styrene-co-(2-(1,2,3,4,5-pentaphenyl-1H-silol-1-yloxy)ethyl methacrylate)] [PEG-b-P(S-co-PPSEMA)]. Their capability of loading doxorubicin (DOX) is investigated by monitoring the loading content, encapsulation efficiency, and photophysical properties of micelles. Forster resonance energy transfer from PPSEMA to DOX is observed in DOX-loaded micelles, which can serve as an indication of successful encapsulation of DOX in these micelles. The application of this new type of fluorescent polymeric micelles as a fluorescent probe and an anticancer drug carrier simultaneously is explored by studying the intracellular uptake of DOX-loaded micelles.
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