Journal
MACROMOLECULAR BIOSCIENCE
Volume 13, Issue 11, Pages 1621-1631Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300228
Keywords
collagen; hydrogels; marine biotechnology; supercritical fluids; tissue engineering
Funding
- European Union Seventh Framework Programme [KBBE-2010-266033]
- FEDER through POCTEP [0330_IBEROMARE_1_P]
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The possibility to fabricate marine collagen porous structures crosslinked with genipin under high pressure carbon dioxide is investigated. Collagen from shark skin is used to prepare pre-scaffolds by freeze-drying. The poor stability of the structures and low mechanical properties require crosslinking of the structures. Under dense CO2 atmosphere, crosslinking of collagen pre-scaffolds is allowed for 16h. Additionally, the hydrogels are foamed and the scaffolds obtained present a highly porous structure. In vitro cell culture tests performed with a chondrocyte-like cell line show good cell adherence and proliferation, which is a strong indication of the potential of these scaffolds to be used in tissue cartilage tissue engineering.
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