Journal
MACROMOLECULAR BIOSCIENCE
Volume 14, Issue 3, Pages 380-389Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300340
Keywords
cell engineering; cerebral ischemia model; cross-linked iron oxide nanoparticles; magnetic resonance imaging; mesenchymal stem cells
Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2010-0022471]
- project of Global Innovative Research Center (GiRC) of NRF
- Intramural Research Program (Global RNAi Carrier Initiative) of KIST
- National Research Foundation of Korea [2010-0022471] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area.
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