Journal
MACROMOLECULAR BIOSCIENCE
Volume 13, Issue 8, Pages 1084-1091Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300052
Keywords
atom transfer radical polymerization (ATRP); micelles; redox polymers; ring-opening polymerization; self-assembly
Funding
- National Science Fund for Distinguished Young Scholars [51025312]
- National Basic Research Program of China [2011CB606203]
- Research Fund for the Doctoral Program of Higher Education of China [20110101110037, 20120101130013]
- State Key Laboratory of Supramolecular Structure and Materials [sklssm201316]
- [NSFC-21174126]
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Poly(D,L-lactide)-SS-poly(2-methacryloyloxyethyl phosphorylcholine) block copolymers conjugated with cholesterol are synthesized by ROP and ATRP using a novel kind of double-dead initiator. This facile strategy not only can endue block copolymers with disulfide bonds, but can also overcome the disadvantages inherent in the synthesis procedure for the copolymers. The resultant biomimetic copolymers can self-assemble into near-monodisperse micelles. Subsequently, they are used as a carrier to encapsulate a hydrophobic dye, and the release can be triggered by a redox reagent, dithiothreitol. MTT study shows that the as-prepared micelles has good biocompatibility to both normal and cancer cells. These properties indicate that these micelles may be used as promising drug delivery vehicles.
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