Journal
MACROMOLECULAR BIOSCIENCE
Volume 13, Issue 9, Pages 1238-1248Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300134
Keywords
alginate lyase; biopolymers; ciprofloxacin; cystic fibrosis; drug delivery
Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [PIP 0214]
- Agencia Nacional de Promocion Cientifica y Tecnica (ANPCyT) [PRH 5.2]
- Universidad Nacional de La Plata [X/545]
- Fundacion Argentina de Nanotecnologia (Argentina)
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A new formulation is described based on biopolymeric microspheres containing alginate lyase (AL) and ciprofloxacin (Cip) for sustainable oral delivery in CF patients. Alginate (ALG) and high-methoxyl pectin (HMP) are selected as the biopolymers to develop a composite matrix. ALG microspheres coated with HMP and ALG-HMP blend are gelled in water/organic solvents mixtures, obtaining Cip encapsulations from 46.0 to 100.0%. ALG-HMP shows a Cip sustainable release profile and is able to encapsulate 90.0% of AL, showing 76.0% enzyme activity after release under simulated intestinal conditions. The developed system is a promising delivery carrier to treat chronic infection of Pseudomonas aeruginosa and to reduce the viscoelasticity of the mucus accumulated into intestine of CF patients.
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