Journal
MACROMOLECULAR BIOSCIENCE
Volume 13, Issue 11, Pages 1520-1530Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300179
Keywords
block copolymers; drug-loading; indomethacin; micelles; poly(E-caprolactone); poly[(meth)acrylic acid]; quercetin
Funding
- European Social Fund
- Belgian Program on Interuniversity Attraction Poles initiated by the Belgian State, the Prime Minister's office [P7/05]
- European Science Foundation - Precision Polymer Materials [P2M]
- [UDA-POKL.04.01.01-00-114/09-00]
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A amphiphilic linear AB, BAB, and star shaped (AB)(3) block copolymers of poly(E-caprolactone) (PCL)/poly(meth)acrylic acid (P(M)AA) are used for the preparation of nanoparticles and drug entrapment, where indomethacin and quercetin are employed as model drugs. Drug loading experiments with the nanoparticles based on PAA block copolymers demonstrate a higher efficiency for the star structure, whereas the PMAA star copolymer presents the lowest entrapment ability. The release properties are studied at room temperature and 37 degrees C in phosphate buffer solutions with pH equal to 5 and 7.4. The kinetic profiles show a strong relation to the copolymer's topology, indicating the lowest release rates from the star based superstructures, while the PMAA particles are less stable than those containing PAA segment(s
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