Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 7, Pages 979-985Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200074
Keywords
antifouling; biomimetic; catechol; coatings; phosphorylcholine
Funding
- National Science Foundation of China [20974087]
- National Institutes of Health from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) [R01 EB005772]
- China Scholarship Council [2006102238]
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A doubly biomimetic PMNC polymer bearing cell antifouling phosphorylcholine and mussel adhesive protein catechol groups is synthesized. The polymer can be deposited onto a variety of substrates by dip-coating in an aqueous solution, adhering to surfaces via the catechol functional group while at the same time forming a cell outer membrane mimetic antifouling surface. Contact angle, ATR-FTIR and XPS measurements confirm polymer coating formation on a variety of inorganic and organic substrates. BSA and bovine plasma fibrinogen protein adsorption on PMNC coated surfaces are reduced significantly compared to unmodified substrates, and platelet adhesion from human serum onto the PMNC coated substrate surfaces is highly suppressed in this study.
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