Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 3, Pages 383-394Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100396
Keywords
cryogels; hydrogels; michael addition; stimuli-sensitive polymers; tissue engineering
Funding
- Ghent University
- Research Foundation Flanders (FWO)
- IWT
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A Michael addition strategy involving the reaction between a maleimide double bond and amine groups is investigated for the synthesis of cryogels at subzero temperature. Low-molecular-weight PEG-based building blocks with amine end groups and disulfide-containing building blocks with maleimide end groups are combined to synthesize redox-responsive PEG cryogels. The cryogels exhibit an interconnected macroporous morphology, a high compressive modulus and gelation yields of around 95%. While the cryogels are stable under physiological conditions, complete dissolution of the cryogels into water-soluble products is obtained in the presence of a reducing agent (glutathione) in the medium. Cell seeding experiments and toxicologic analysis demonstrate their potential as scaffolds in tissue engineering.
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