Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 8, Pages 1114-1123Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200080
Keywords
biocompatibility; biomaterials; hydrolysis; poly(2-oxazoline)s; stability
Funding
- Ghent University
- Ghent University via Concerted Research Actions [BOF11/GOA/023]
- FWO-Flanders
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The hydrolysis of PEtOx is studied to evaluate the potential toxicity of partially hydrolyzed polymers that might interfere with its increasing popularity for biomedical applications. The hydrolysis of PEtOx is studied in the presence of digestive enzymes (gastric and intestinal) and at 5.8?M hydrochloric acid as a function of temperature (57, 73, 90, and 100?degrees C). It is found that PEtOx undergoes negligible hydrolysis at 37?degrees C and that thermal and solution properties are not altered when up to 10% of the polymer backbone is hydrolyzed. Mucosal irritation and cytotoxicity is also absent up to 10% hydrolysis levels. In conclusion, PEtOx will not decompose at physiological conditions, and partial hydrolysis will not limit its biomedical applications.
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