Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 9, Pages 1279-1289Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200052
Keywords
antimicrobial; biomimetic; peptides; poly(ethylene imine); structure-property relations
Funding
- NSF CAREER Award [DMR-0845592]
- NIH [5R21DE020908-02, 1R15GM094330]
- Department of Biologic and Materials Sciences, University of Michigan School of Dentistry
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0845592] Funding Source: National Science Foundation
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We report the structureactivity relationship in the antimicrobial activity of linear and branched poly(ethylene imine)s (L- and B-PEIs) with a range of molecular weights (MWs) (50012?000). Both L- and B-PEIs displayed enhanced activity against Staphylococcus aureus over Escherichia coli. Both B- and L-PEIs did not cause any significant permeabilization of E. coli cytoplasmic membrane. L-PEIs induced depolarization of S. aureus membrane although B-PEIs did not. The low MW B-PEIs caused little or no hemolysis while L-PEIs are hemolytic. The low MW B-PEIs are less cytotoxic to human HEp-2 cells than other PEIs. However, they induced significant cell viability reduction after 24 h incubation. The results presented here highlight the interplay between polymer size and structure on activity.
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