Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 7, Pages 926-936Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200026
Keywords
cell adhesion; polymer brushes; polyoxazolines; protein adsorption; surface-initiated polymerization
Funding
- CompInt (International Graduate School of complex interface) of the TU Munchen
- IGSSE (International Graduate School for Science and Engineering)
- Center for Regenerative Therapies Dresden (CRTD)
- King Abdullah University of Science and Technology (KAUST) [KUK-F1-029-32]
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POx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption.
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