Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 11, Pages 1566-1574Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200195
Keywords
collagen; cylindrical configuration; electrospinning; silk fibroin; vascular grafts
Funding
- Fondazione Cariplo, Italy [2007-5457]
- Natural Science and Engineering Research Council of Canada
- Quebec Hospital Research Center, St Francois d'Assise Hospital in Quebec City, Canada
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None of the replacements proposed in the literature for small-calibre blood vessels (SCBV) fully satisfies the stringent requirements that these grafts have to fulfil. Here, an electrospun silk fibroin tubular construct is hybridized with type I collagen gel to produce a biomimetic SCBV graft with physiologically relevant compliance and burst pressure and optimal cytocompatibility. The hybridization of the two polymers results in the formation of a nanofibrillar hydrated matrix, where the collagen gel enhances the mechanical properties of the SF tubular construct and improves the early response of the material to in vitro cell adhesion and proliferation.
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