Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 6, Pages 724-739Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100435
Keywords
biosensors; gold nanoparticles; sensors; surface plasmon resonance (SPR); surfaces
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SPR biosensing is increasingly popular for the detection of a multitude of biomolecules. It offers label-free detection and study of proteins, nucleic acids, and other biomolecules in real time. A recent trend involves incorporation of AuNPs, either within the sensing surface itself or as signal enhancing tagging molecules. The importance of AuNP and detecting agent spacing is described and techniques using macromolecular spacing aids are highlighted. Recent methods to enhance SPR detection capabilities using gold nanoparticles are reviewed, as well as device fabrication and the results of incorporation. SPR detection is a highly versatile method for the detection of biomolecules and, with the incorporation of AuNPs, shows promise in extending it to a number of new applications.
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