Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 7, Pages 962-969Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000510
Keywords
biocompatibility; drug delivery systems; nanogels; N-carboxy-anhydride (NCA); polypeptides
Funding
- National Natural Science Foundation of China [20874095, 51073147]
- National Major Specific Project for Innovation of New Pharmaceuticals [2009ZX09103-715]
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A novel disulfide core cross-linked PEGylated polypeptide nanogel has been synthesized by a one-step ring opening copolymerization of gamma-benzyl L-glutamate N-carboxyanhydride and L-cystine N-carboxyanhydride using an amino group-terminated poly(ethylene glycol) methyl ether as initiator. Characterization of products confirms the formation of a core cross-linked PEGylated nanogel with disulfide linkages with a size of about 250 nm, and these studies also confirm that this nanogel can easily be broken by glutathione. Cell viability experiments show the good biocompatibility of the as-prepared polymer. Studies relating to loading and controlled release of indomethacin under reduction-sensitive conditions reveal that the nanogel is a good candidate for drug delivery systems.
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