Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 6, Pages 839-847Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000434
Keywords
antitumor; drug delivery systems; gelatin; nanoparticles; polyoxometalates
Funding
- National Natural Science Foundation of China [50625311, 20874042, 51033002]
- MOST [2009ZX09503-028]
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Surfactant-free gelatin/heptamolybdate (HM) hybrid nanoparticles are prepared by a simple and environmentally friendly approach utilizing the electrostatic interaction between anionic HM and the zwitterionic gelatin. The obtained nanoparticles have a tunable size and very high HM loading content up to about 70%. In vitro and in vivo experiments prove that the gelatin/HM hybrid nanoparticles exhibit significantly better antitumor activity than plain ammonium heptamolybdate solution. Therefore, the gelatin/HM hybrid nanoparticles reported here may serve as a prototype platform for polymer/polyoxometalate (POM) hybrid nanoparticles as cancer treatment agents and hence open up more opportunities to maximize the potential of POM-based pharmaceutical agents.
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