Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 9, Pages 1169-1174Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100088
Keywords
amphiphiles; biomimetics; gene delivery; micelles; polymers
Funding
- National Research Foundation of Korea
- Ministry of Education, Science and Technology [2010-0088722, 2010-0059223, 2010-0027955, 2010-0093632]
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Efficient gene transfer into mammalian cells mediated by small molecular amphiphile-polymer conjugates, bile acid-polyethylenimine (BA-PEI), is demonstrated, opening an efficient transport route for genetic materials across the cell membrane. This process occurs without the aid of endocytosis or other energy-consuming processes, thus mimicking macromolecular transduction by cell-penetrating peptides. The exposure of a hydrophilic face of the amphiphilic BA moiety on the surface of BA-PEI/DNA complex that mediates direct contact of the BA molecules to the cell surface seems to play an important role in the endocytosis- and energy-independent internalization process. The new modality of the polymeric biomimetics can be applied to enhanced delivery of macromolecular therapeutics.
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