Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 12, Pages 1637-1646Publisher
WILEY-BLACKWELL
DOI: 10.1002/mabi.201100226
Keywords
biomaterials; hydrolytic degradation; polymer networks; poly(propylene glycol); poly(rac-lactide)
Funding
- Bundesministerium fur Bildung und Forschung (BMBF) [0311867]
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For polymer-based degradable implants, mechanical performance and degradation behavior need to be precisely controlled. Based on a rational design, this work comprehensively describes the properties of photo-crosslinked polymer networks prepared from poly(rac-lactide)-block-poly(propylene glycol)-block-poly(rac-lactide) dimethacrylate precursors during degradation. By varying the length of poly(rac-lactide) blocks connected to a central 4?kDa polyether block, microphase separated networks with adjustable crosslinking density, hydrophilicity/hydrophobicity ratio, thermal, and mechanical properties are obtained. The materials are characterized by a low water uptake, controlled mass loss, and slowly decreasing wet-state E moduli in the kPa range.
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