Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 1, Pages 83-92Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100197
Keywords
bioimaging; drug delivery; micelles; porphyrin star-shaped copolymer
Funding
- Natural Science Foundation of China [51033002, 50802040, 20874042]
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Star-shaped poly(e-caprolactone)-b-poly(ethylene oxide) amphiphilic copolymer with a tetrakis-(4-aminophenyl)-terminated porphyrin core was synthesized. Paclitaxel (PTX)-loaded polymeric micelles were prepared by the self-assembly of the star copolymer and in situ encapsulation of PTX. The fluorescent characteristic of the porphyrin moiety allowed the cellular uptake and biodistribution of the PTX-loaded micelles to be monitored by fluorescent imaging. The PTX-loaded micelles can be readily internalized by cancer cells and have a slightly higher cytotoxicity than clinic PTX injection Taxol. In vivo real-time fluorescent imaging revealed that the micelles could accumulate at tumor site via the blood circulation in tumor-bearing mice. In vivo antitumor efficacy examinations indicated that the PTX-loaded micelles had significantly superior efficacy in impeding tumor growth than Taxol and low toxicity to the living mice.
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