Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 3, Pages 402-411Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100333
Keywords
adhesion; electrospinning; PC12 cells; polyaniline; poly[(L-lactide)-co-(e-caprolactone)]
Funding
- National Research Foundation (NRF) of Korea
- Korean Government (MEST) [2010-0002089]
- Ministry of Education, Science and Technology [2010-0002176]
- Ministry of Health and Welfare, Republic of Korea [2010-0020352]
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Blends of PAni and PLCL are electrospun to prepare uniform fibers for the development of electrically conductive, engineered nerve grafts. PC12 cell viability is significantly higher on RPACL fibers than on PLCL-only fibers, and the electrical conductivity of the fibers affects the differentiation of PC12?cells; the number of cells positively-stained and their expression level are significantly higher on RPACL fibers. PC12 cell bodies display an oriented morphology with outgrowing neurites. On RPACL fibers, the expression level of paxillin, cdc-42, and rac is positively affected and proteins including RhoA and ERK exist as more activated state. These results suggest that electroactive fibers may hold promise as a guidance scaffold for neuronal tissue engineering.
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