Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 4, Pages 535-548Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000374
Keywords
adhesion; click reaction; coatings; functionalization of polymers; glycopolymer
Funding
- Dutch Polymer Institute (DPI, Technologic Area HTE)
Ask authors/readers for more resources
An efficient and metal-catalyst free method of glycopolymer synthesis via thiol/para-fluorine click'' reaction was used to graft acetylated 1-thio-beta-D-glucopyranose and 1-thio-beta-D-galactopyranose onto a homopolymer of pentafluorostyrene (PFS) as well as onto a block copolymer of styrene and PFS. Subsequent deprotection of the carbohydrate moieties yielded well-defined, sugar-modified polymers (PDI < 1.2). The prepared polymers were not cytotoxic against 3T3 fibroblasts and MC3T3-E1 preosteoblasts. Furthermore, the water-insoluble copolymers were drop-cast and examined as synthetic biocompatible coatings on poly(propylene) substrates for culturing the investigated cell types. Both fibro- and preosteoblasts showed stable adhesion and proliferation on the glycopolymer-coated surfaces.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available