Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 4, Pages 557-564Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000437
Keywords
adhesion; atom transfer radical polymerization (ATRP); biological application of polymers; imaging
Funding
- Japan Society for the Promotion of Science (JSPS) [22350101]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [20106007]
- Grants-in-Aid for Scientific Research [22300152, 20106007, 22350101] Funding Source: KAKEN
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A CMB monomer was polymerized on a glass plate with a surface-confined ATRP initiator containing a 2-bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non-specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furthermore, the PCMB brush was ablated and a hollow space with a designed shape could be made to which HEK293 cells (from human embryonic kidney) and Hep G2 (from human hepatoma) cells non-specifically adhered, while no adhesion of these cells to the non-treated area on the brush was observed. The present results clearly indicate the usefulness of ion beam-printed patterns of anti-biofouling zwitterionic polymer brushes in the biomedical field.
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