Non-Woven Fibrous Materials with Antibacterial Properties Prepared by Tailored Attachment of Quaternized Chitosan to Electrospun Mats from Maleic Anhydride Copolymer

In order to impart antibacterial properties to microfibrous electrospun materials from styrene/maleic anhydride copolymers, quaternized chitosan derivatives (QCh) containing alkyl substituents of different chain lengths are covalently attached to the mats. A complete inhibition of the growth of bacteria, S. aureus (Gram-positive) and E. coli (Gram-negative), for a contact time of 30120?min or a decrease of the bacterial titer by 23 log units is observed depending on the quaternization degree, the chain length of the alkyl substituent, and the molar mass of QCh. The modified mats are also effective in suppressing the adhesion of pathogenic S. aureus bacteria.