Journal
MACROMOLECULAR BIOSCIENCE
Volume 10, Issue 10, Pages 1152-1163Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900448
Keywords
amyloid-beta peptides; cytotoxicity; nanoparticles; oligomers; polystyrene
Funding
- Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) [SFRH/BD/18465/2004]
- Max Planck Society
- FCT [PTDC/BIO/69359/2006]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/18465/2004, PTDC/BIO/69359/2006] Funding Source: FCT
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The amyloid-beta peptide (A beta) plays a central role in the mechanism of Alzheimer's disease, being the main constituent of the plaque deposits found in AD brains. A beta amyloid formation and deposition are due to a conformational switching to a beta-enriched secondary structure. Our strategy to inhibit A beta aggregation involves the reconversion of A beta conformation by adsorption to nanoparticles. NPs were synthesized by sulfonation and sulfation of polystyrene, leading to microgels and latexes. Both polymeric nanostructures affect the conformation of AB inducing an unordered state. Oligomerization was delayed and cytotoxicity reduced. The proper balance between hydrophilic moieties and hydrophobic chains seems to be an essential feature of effective NPs.
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