Journal
MACROMOLECULAR BIOSCIENCE
Volume 10, Issue 1, Pages 91-100Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900168
Keywords
electrospinning; gelatin; polycaprolactone; skeletal muscles; tissue engineering
Funding
- Ministry of Health & Welfare, Republic of Korea [A080189]
- Korea Health Promotion Institute [A080189] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Composite nano-fibers of poly(caprolactone) (PCL) and gelatin crosslinked with genipin are prepared. The contact angles and mechanical properties of crosslinked PCL-gelatin nanofibers decrease as the gelatin content increases. The proliferation of myoblasts is higher in the crosslinked PCL-gelatin nanofibers than in the PCL nanofibers, and the formation of myotubes is only observed on the crosslinked PCL-gelatin nanofibers. The expression level of myogenin, myosin heavy chain, and troponin T genes is increased as the gelatin content is increased. The results suggest that PCL-gelatin nanofibers crosslinked with genipin can be used as a substrate to modulate proliferation and differentiation of myoblasts, presenting potential applications in muscle tissue engineering.
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