Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 3, Pages 338-343Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000333
Keywords
doxorubicin; pH-response; polymeric vesicles; polyphosphazenes; self-assembly
Funding
- National Nature Science Foundation of China [30873203]
- Key Program of Science & Technology Department of Zhejiang Province [2009C14008]
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pH-Responsive amphiphilic graft macromolecules consisting of a polyphosphazene backbone, hydrophilic PEG branches and pH-sensitive DPA were successfully synthesized and characterized. The copolymer can self-assemble into vesicles in an aqueous solution with unique inner structure and homogeneously encapsulate both lipophilic and hydrophilic molecules. The pH-dependent structure change of vesicles was also observed by DLS and TEM. Dox-loaded vesicles exhibit a sharp pH-responsive drug release profile and dramatically enhance the cytotoxicity of Dox against Dox-resistant MCF-7/adr cells. These results suggest such vesicles based on pH-responsive polyphosphazene hold great potential for specific drug therapy.
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