Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 2, Pages 192-198Publisher
WILEY-BLACKWELL
DOI: 10.1002/mabi.201000238
Keywords
atom transfer radical polymerization (ATRP); grafting from; N-carboxyanhydride (NCA); polypeptide; thermal properties
Funding
- National Natural Science Foundation of China [50733003, 20904053, 50973108, 50425309]
- Program of Scientific Development of Jilin Province [20090135]
- Chinese Academy of Sciences [KJCX2-YW-H19]
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Because of their favorable biodegradability, biocompatibility,regular secondary structures, and stimuli-responsiveness, synthetic polypeptides have attracted more and more attention in the biomedical material field. In this work, a novel thermo-responsive graft polypeptide, poly(L-glutamate)-graft-poly(2-(2-methoxyethoxy) ethyl methacrylate) (PLG-g-PMEO(2)MA), is prepared through a combination of ring-opening polymerization and atom transfer radical polymerization. The structure of PLG-g-PMEO(2)MA is confirmed by FT-IR, (1)H NMR, and GPC analyses. The phase transition temperature of PLG-g-PMEO(2)MA is adjustable by varying the NaCl concentration in aqueous solution. PLG-g-PMEO(2)MA adopts alpha-helical conformations both in aqueous solution at 25 and 60 degrees C and even in the solid state. In addition, PLG-g-PMEO(2)MA forms stimuli-responsive micelles with an alpha-helical core and a thermo-responsive shell in water.
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