Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 1, Pages 72-76Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000261
Keywords
biomaterials; fibroblast growth factor-2; glycosaminoglycan; layer-by-layer; polyelectrolytes
Funding
- National Science Foundation [DMR 0847641]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0847641] Funding Source: National Science Foundation
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A new method is presented for functionalizing electrospun nanofibers with GAGs and growth factors by PEM deposition. Electrospun chitosan nanofibers, spun from trifluoroacetic acid and dichloromethane, were coated with PEMs, using the polysaccharides heparin and N,N,N-trimethyl chitosan. FGF-2 was adsorbed on the PEM-coated nanofibers. Nanofiber neutralization, PEM construction, and FGF-2 adsorption were monitored using FT-IR spectroscopy and X-ray photoelectron spectroscopy. Alcian blue staining was used to confirm the presence of heparin. SEM was used to study nanofiber morphology.
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