Journal
MACROMOLECULAR BIOSCIENCE
Volume 10, Issue 3, Pages 307-316Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900248
Keywords
collagen gel; crosslinking; mechanical properties; scaffolds; vascular tissue engineering
Funding
- Canadian Bureau for International Education (CBIE)
- Natural Science and Engineering Research Council of Canada
- Centre Hospitalier Universitaire de Quebec, Hopital Saint-Francois d'Assise
Ask authors/readers for more resources
Collagen-based vascular substitutes represent in VTE a valid alternative for the replacement of diseased small-calibre blood vessels. In this study, collagen gel-based scaffolds were crosslinked combining modulation of pH and UV-C radiation. The effects on the mechanical properties, on the molecular structure and on cell viability and morphology were investigated. The I mechanical response increased as a function of pH or UV-C dose and strongly depended on the test speed. Collagen molecular conformation resulted only slightly modified. While cell adhesion was not significantly altered, cell proliferation partially decreased in function of pH and UV-C. These findings suggest that UV-C treated collagen gels can represent an adequate substrate for VTE applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available