Journal
MACROMOLECULAR BIOSCIENCE
Volume 10, Issue 10, Pages 1203-1209Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000031
Keywords
biodegradable; copolymers; macromonomers; polylactide; radical polymers
Funding
- MEXT, Japan [19105003, 21655043, 21550120, 21106519]
- Waseda University
- National Natural Science Foundation of China [50773081, 50973108]
- Grants-in-Aid for Scientific Research [21550120, 21655043, 21106519] Funding Source: KAKEN
Ask authors/readers for more resources
Copolymers composed of PLA and PTAm were prepared by a macromonomer approach. The PLA bearing vinyl group at chain end was copolymerized with 2,2,6,6-tetrametylpiperidine-4-ylacrylamide. The resulted copolymers were oxidized by a peroxide to give PTAm-g-PLA. The structures of the copolymers were confirmed by NMR and FTIR spectroscopy. The comparison of H-1 NMR results and SQUID measurements demonstrated that the oxidation of the PTAm fragment proceeded almost to completion. An MTT assay, cell adhesion and spreading evaluation showed that the copolymers exhibited improved cytocompatibility as compared to the PTAm homopolymer due to the introduction of the biocompatible PLA moiety.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available