Journal
MACROMOLECULAR BIOSCIENCE
Volume 10, Issue 6, Pages 632-637Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900378
Keywords
biodegradable; hyperbranched; oligomers; RAFT
Funding
- Australian Research Council
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A novel PEGylated biodegradable hyperbranched PEG-b-PDMAEMA has been synthesized. The low toxicity, small molecular weight PDMAEMA chains were crosslinked using a biodegradable disulfide-based dimethacrylate (DSDMA) agent to yield higher molecular weight hyperbranched polymers. PEG chains were linked onto the polymer surface, masking the positive charge (as shown by Zeta potential measurements) and reducing the toxicity of the polymer. The hyperbranched structures were also cleaved under reducing conditions and analyzed, confirming the expected component structures. The hyperbranched polymer was mixed with DNA and efficient binding was shown to occur through electrostatic interactions. The hyperbranched structures could be reduced easily, Oligomer generating lower toxicity oligomer chains.
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