4.7 Article

Hemostatic Efficacy of Biological Self-Assembling Peptide Nanofibers in a Rat Kidney Model

Journal

MACROMOLECULAR BIOSCIENCE
Volume 10, Issue 1, Pages 33-39

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900129

Keywords

hemostatic efficacy; kidney injury; self-assembly peptide

Funding

  1. Sichuan University of the Education Ministry of China
  2. National Natural Science Foundation of China (NSFC) [50775152/E051204]

Ask authors/readers for more resources

We evaluated the hemostatic efficacy of a biological self-assembling peptide RADA16-I in a rat kidney injury model. Adult male rats were randomized into five groups: sham operation (no renal excision), no hemostatic agent (control), commercially available gelatin sponge (Gelfoam), 1% RADA16-I, and 2% RADA16-I. After left partial nephrectomy, the anesthetized animal was anticoagulated using 300 IU.kg(-1) heparin, and the topical hemostatic agent was applied to the injury. Blood loss and mean arterial pressure (MAP) were recorded. As was the case for Gelfoam, 2% RADA16-I produced marked hemostasis versus controls (p < 0.01). Blood loss with 1% and 2% RADA16-I was significantly less than controls. The decline in MAP during surgery was less with 2% versus 1% RADA16-I. RADA16-I also resulted in less histological tissue responses than Gelfoam. These data suggest that RADA16-I can stop hemorrhage, with only minimal tissue responses, in experimental renal injury.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available