Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 2, Pages 219-233Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000293
Keywords
drug delivery systems; micelles; peptides; reversible addition fragmentation chain transfer (RAFT)
Funding
- Australian Research Council (ARC) [DP110102409]
- Centre for Advanced Macromolecular Design
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Block copolymers were prepared via RAFT polymerization with P(PEGMEMA) as the hydrophilic block to form micelles for the controlled delivery of ABZ. The group contribution method was used to estimate the partial solubility parameters for ABZ and various polymers as potential core-forming block to achieve optimum compatibility. Different ratios between MMA and LMA, a non-compatible monomer, were prepared. Cytotoxicity tests revealed a high toxicity of the ABZ-loaded micelle resulting in 80% cell deaths at a micelle concentration of 10 mu g . mL(-1). Cellular uptake of micelles has been studied using fluorescently labeled micelles, showing that a large fraction of micelles is readily taken up by OVCAR-3 cells. RGD-conjugated micelles were prepared and showed an increased cellular uptake.
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