Journal
MACROMOLECULAR BIOSCIENCE
Volume 10, Issue 6, Pages 621-631Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200900434
Keywords
drug delivery systems; poly(epsilon-caprolactone); poly-ethylene (PE); nanoparticles; thermal properties
Funding
- National Natural Science Foundation of China [50873109, 50830103]
- Chinese Academy of Sciences [KJCX2-YW-H19]
- Center for Molecular Science of ICCAS
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Thermosensitive nanoparticles with a core-shell structure were prepared by self-assembly of PCL-b-PEO-b-PNIPAAm triblock copolymers, which were synthesized by anionic ring-opening polymerization and reversible addition fragmentation chain transfer (RAFT) polymerization. At temperatures above the lower critical solution temperature (LCST), the collapse of PNIPAAm chains in the outer shell and in the core of nanoparticle caused a decrease in size, while the constantly hydrophilic PEO chains in the shell endowed nanoparticles with excellent stability in water. The release of doxorubicin from these nanoparticles showed that both the length of PNIPAAm chains and temperature have great influence on drug release, which indicates the great potential of thermosensitive nanoparticles as drug carriers.
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