Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 3, Pages 268-278Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800164
Keywords
biocompatibility; chitosan; films; layer growth; polyelectrolytes
Funding
- National Natural Science Foundation of China [50473061]
- Science and Technology Committee of Shanghai City [08JC1410300]
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A new biocompatible film based on chitosan and poly(L-glutamic acid) (CS/PGA), created by alternate deposition of CS and PGA, was investigated. FT-IR spectroscopy, UV-vis spectroscopy and QCM were used to analyze the build-up process. The growth of CS and PGA deposition are both exponential to the deposition steps at first. After about 9 (CS/PGA) depositions, the exponential to linear transition takes place. QCM measurements combined with UV-vis spectra revealed the increase in the multilayer film growth at different pH (4.4, 5.0 and 5.5). The build-up of the multilayer stops after a few depositions at pH = 6.5. A muscle myoblast cell (C2C12) assay showed that (CS/PGA)(n) multilayer films obviously promote C2C12 attachment and growth.
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