Journal
MACROMOLECULAR BIOSCIENCE
Volume 9, Issue 8, Pages 744-753Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800366
Keywords
core/shell polymers; drug delivery systems; micelles; synthesis; thermosensitive
Funding
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1032186] Funding Source: National Science Foundation
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Thermosensitive PNVCL-b-PEG block copolymer coupled with folic acid was prepared as an anti-cancer drug carrier. This polymer self-assembled into stable micelles in aqueous solutions at above 33 degrees C. At 37 degrees C, the release profile of PNVCL-b-PEG-FA micelles showed a slower andmore controlled release of the entrapped 5-FU than that at 25 degrees C. The blank and 5-FU-loaded PNVCL-b-PEG-FA micelles did not induce remarkable cytotoxicity against the EA.hy 926 human endothelial cell line; however, 5-FUloaded PNVCL-b-PEG-FA micelles showed a cytotoxicity effect against 4T1 mouse mammary carcinoma cells due to the availability of loaded anti-cancer drugs delivered to the inside of the cancer cells by the folate-receptor-mediated endocytosis process.
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